Abstract
RNA-binding proteins regulate every aspect of RNA metabolism, including pre-mRNA splicing, mRNA trafficking, stability, and translation. This review summarizes the available information on molecular mechanisms of translational repression by RNA-binding proteins. By using a specific set of well-defined examples, we also describe how regulation can be reversed.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Gene Silencing
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Models, Biological
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Protein Biosynthesis*
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RNA Caps / genetics
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RNA Caps / metabolism
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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RNA-Binding Proteins / genetics*
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RNA-Binding Proteins / metabolism*
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Repressor Proteins / genetics
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Repressor Proteins / metabolism
Substances
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RNA Caps
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RNA, Messenger
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RNA-Binding Proteins
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Repressor Proteins