Late-appearing Philadelphia chromosome in childhood acute myeloid leukemia

Niketa Shah; Michael T Leaker; Ikuko Teshima; Sylvain Baruchel; Mohamed Abdelhaleem; Charles C Ye

doi:10.1002/pbc.21317

Late-appearing Philadelphia chromosome in childhood acute myeloid leukemia

Pediatr Blood Cancer. 2008 May;50(5):1052-3. doi: 10.1002/pbc.21317.

Authors

Niketa Shah¹, Michael T Leaker, Ikuko Teshima, Sylvain Baruchel, Mohamed Abdelhaleem, Charles C Ye

Affiliation

¹ Department of Paediatrics, Division of Haematology and Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.

PMID: 18213712
DOI: 10.1002/pbc.21317

Abstract

A 3-year-old female was diagnosed with acute myeloid leukemia (AML-M2). The disease was refractory to various chemotherapeutic agents. Cytogenetic analysis revealed a clone with trisomy 8 at diagnosis that was replaced by a clone containing a t(11;15) and del(20q) by the end of the second induction. A new clone, characterized by a Philadelphia chromosome, with the minor BCR/ABL p190 transcript, emerged 14 months after diagnosis and remained to the end of disease course. The late occurrence of the Philadelphia chromosome in AML has been documented rarely in adults.

Publication types

Case Reports

MeSH terms

Blast Crisis
Child, Preschool
Chromosomes, Human, Pair 11 / genetics
Chromosomes, Human, Pair 15 / genetics
Chromosomes, Human, Pair 20 / genetics
Chromosomes, Human, Pair 8 / genetics
Female
Fusion Proteins, bcr-abl / genetics
Humans
Immunophenotyping
In Situ Hybridization, Fluorescence
Karyotyping
Leukemia, Myeloid, Acute / genetics*
Leukemia, Myeloid, Acute / pathology
Leukemia, Myeloid, Acute / therapy
Philadelphia Chromosome*
RNA, Messenger / genetics
RNA, Messenger / metabolism
Reverse Transcriptase Polymerase Chain Reaction
Translocation, Genetic
Trisomy

Substances

RNA, Messenger
Fusion Proteins, bcr-abl