Soluble fragment of HER2/neu receptor in the serum of patients with breast cancer with different levels of this protein expression in the tumor

N E Kushlinskii; V P Shirokii; E S Gershtein; V D Yermilova; G Yu Chemeris; V P Letyagin

doi:10.1007/s10517-007-0153-4

Soluble fragment of HER2/neu receptor in the serum of patients with breast cancer with different levels of this protein expression in the tumor

Bull Exp Biol Med. 2007 Apr;143(4):449-51. doi: 10.1007/s10517-007-0153-4.

Authors

N E Kushlinskii¹, V P Shirokii, E S Gershtein, V D Yermilova, G Yu Chemeris, V P Letyagin

Affiliation

¹ N. N. Blokhin National Oncological Research Center, Russian Academy of Medical Sciences, Moscow.

PMID: 18214297
DOI: 10.1007/s10517-007-0153-4

Abstract

Serum level of soluble HER2/neu in patients with tumors characterized by high expression of this protein (2+/3+ according to immunohistochemical analysis) was significantly higher than in patients with low expression of HER2/neu and in women with benign diseases of the mammary glands. The level of HER2/neu in the serum decreased after removal of the primary tumor in the majority of patients.

MeSH terms

Breast / chemistry
Breast / pathology
Breast / surgery
Breast Diseases / blood
Breast Diseases / metabolism
Breast Diseases / pathology
Breast Neoplasms / blood*
Breast Neoplasms / metabolism
Breast Neoplasms / pathology
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunohistochemistry
Receptor, ErbB-2 / analysis
Receptor, ErbB-2 / blood*

Substances

Receptor, ErbB-2