Abstract
The bioassay-guided fractionation of the MeOH extract from the root of Sophora flavescens led to the isolation of eight known prenylated flavonoids ( 1 - 8) responsible for the IN VITRO anti-allergic activity. Among them, kushenol N ( 3), sophoraflavanone G ( 6), and leachianone A ( 7) demonstrated significant inhibition of the release of beta-hexosaminidase from cultured RBL-2H3 cells with IC (50) values ranging from 15 to 30 muM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Allergic Agents / isolation & purification
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Anti-Allergic Agents / pharmacology*
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Cell Line, Tumor
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Flavonoids / isolation & purification
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Flavonoids / pharmacology*
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Leukemia, Basophilic, Acute
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Plant Roots / chemistry*
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Rats
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Sophora / chemistry*
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beta-N-Acetylhexosaminidases / antagonists & inhibitors
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beta-N-Acetylhexosaminidases / metabolism
Substances
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Anti-Allergic Agents
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Flavonoids
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beta-N-Acetylhexosaminidases