Abstract
Preclinical studies carried out over the last seven years by our group have focused on the development of a group A streptococcal (GAS) vaccine based on the antiphagocytic bacterial surface M protein using the Lipid-Core Peptide (LCP) system. This synthetic peptide vaccine delivery system has several advantages over other delivery systems including its self-adjuvanting properties and the ability to incorporate multiple peptide epitopes into a single vaccine. This review describes various vaccine delivery strategies including the LCP system, highlighting its functional properties and applications in vaccine research using data obtained from various LCP-based GAS vaccine candidates evaluated in murine models.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Antigens, Bacterial / chemistry
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Bacterial Outer Membrane Proteins / chemistry
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Carrier Proteins / chemistry
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Humans
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Lipids / chemistry*
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Molecular Sequence Data
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Peptides / chemical synthesis*
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Peptides / chemistry*
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Streptococcal Vaccines / administration & dosage
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Streptococcal Vaccines / chemical synthesis*
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Streptococcal Vaccines / chemistry*
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Streptococcus pyogenes / immunology*
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Vaccines, Synthetic / administration & dosage
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Vaccines, Synthetic / chemistry
Substances
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Antigens, Bacterial
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Bacterial Outer Membrane Proteins
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Carrier Proteins
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Lipids
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Peptides
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Streptococcal Vaccines
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Vaccines, Synthetic
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streptococcal M protein