Influenza virus hemagglutinin--structural studies and their implications for the development of therapeutic approaches

James Stevens; Ruben O Donis

doi:10.2174/187152607783018727

Influenza virus hemagglutinin--structural studies and their implications for the development of therapeutic approaches

Infect Disord Drug Targets. 2007 Dec;7(4):329-35. doi: 10.2174/187152607783018727.

Authors

James Stevens¹, Ruben O Donis

Affiliation

¹ Influenza Division, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA. [email protected]

PMID: 18220964
DOI: 10.2174/187152607783018727

Abstract

Possible adaptation of one of the currently circulating strains of highly pathogenic H5N1 avian influenza A virus to produce the next human influenza pandemic is an area of major global concern. Intense research is being focused on developing new generations of effective vaccines and antivirals. Here, we discuss the structure of hemagglutinin and its potential as a target for development of future therapeutics to mitigate the impact of any future influenza pandemic.

Publication types

Review

MeSH terms

Animals
Birds / virology
Communicable Disease Control
Disaster Planning
Disease Outbreaks / prevention & control*
Hemagglutinin Glycoproteins, Influenza Virus* / chemistry
Hemagglutinin Glycoproteins, Influenza Virus* / genetics
Hemagglutinin Glycoproteins, Influenza Virus* / immunology
Humans
Influenza A Virus, H5N1 Subtype / genetics
Influenza A Virus, H5N1 Subtype / immunology*
Influenza A Virus, H5N1 Subtype / pathogenicity*
Influenza Vaccines / therapeutic use
Influenza, Human / immunology
Influenza, Human / prevention & control*
Structure-Activity Relationship

Substances

Hemagglutinin Glycoproteins, Influenza Virus
Influenza Vaccines