Effect of tetrapeptide pancragene on functional morphology of the pancreas in rats with experimental diabetes mellitus

I M Kvetnoi; A P Ryzhak; I N Kostyuchek; Yu A Tafeev

doi:10.1007/s10517-007-0114-y

Effect of tetrapeptide pancragene on functional morphology of the pancreas in rats with experimental diabetes mellitus

Bull Exp Biol Med. 2007 Mar;143(3):368-71. doi: 10.1007/s10517-007-0114-y.

Authors

I M Kvetnoi¹, A P Ryzhak, I N Kostyuchek, Yu A Tafeev

Affiliation

¹ St. Petersburg Institute of Bioregulation and Gerontology, NorthWestern Branch of the Russian Academy of Medical Sciences.

PMID: 18225766
DOI: 10.1007/s10517-007-0114-y

Abstract

The regulatory effect of tetrapeptide pancragene on the morphology and function of pancreatic tissues was shown in rats with diabetes mellitus, which suggests good prospects of this drug.

MeSH terms

Animals
Apoptosis / drug effects
Cell Proliferation / drug effects
Diabetes Mellitus, Experimental / drug therapy*
Diabetes Mellitus, Experimental / pathology
Diabetes Mellitus, Experimental / physiopathology
Glucagon / biosynthesis
Insulin / biosynthesis
Oligopeptides / pharmacology*
Pancreas / drug effects*
Pancreas / pathology
Pancreas / physiopathology
Proliferating Cell Nuclear Antigen / metabolism
Rats
Tumor Suppressor Protein p53 / metabolism

Substances

Insulin
Oligopeptides
Proliferating Cell Nuclear Antigen
Tumor Suppressor Protein p53
lysyl-glutamyl-aspartyl-tryptophan
Glucagon