Abstract
The microbicide candidate octylglycerol inactivates sexually transmitted bacterial pathogens at concentrations which spare normal vaginal flora (lactobacillus). Standard minimum microbicidal concentration assays and time-kill assays revealed the drug concentrations and times required for inactivation. Octylglycerol concentrations must exceed the binding capacity of any human serum albumin to be effective.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Colony Count, Microbial
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Female
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Glyceryl Ethers / chemistry
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Glyceryl Ethers / pharmacology*
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Haemophilus ducreyi / drug effects*
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Haemophilus ducreyi / growth & development
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Humans
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Lactobacillus / drug effects*
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Lactobacillus / growth & development
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Microbial Sensitivity Tests
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Neisseria gonorrhoeae / drug effects*
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Neisseria gonorrhoeae / growth & development
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Streptococcus agalactiae / drug effects*
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Streptococcus agalactiae / growth & development
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Vagina / microbiology
Substances
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1-O-octyl-sn-glycerol
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Anti-Bacterial Agents
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Glyceryl Ethers