Preliminary evidence for lipid peroxidation and changes in pro-oxidant status in brain tissue and blood in ethanol intoxicated rats

I Mihăilescu; M Mohora; V Dinu

Preliminary evidence for lipid peroxidation and changes in pro-oxidant status in brain tissue and blood in ethanol intoxicated rats

Rev Roum Physiol (1990). 1991 Jul-Dec;28(3-4):133-7.

Authors

I Mihăilescu¹, M Mohora, V Dinu

Affiliation

¹ Department of Biochemistry, University of Medicine and Pharmacy Carol Davila, Bucharest, Romania.

PMID: 1823582

Abstract

A single dose of ethanol to rats (6 g ethanol/kg body weight) resulted in an increase of lipid-peroxidation in brain, a decrease of anti oxidant enzyme activity in blood serum and alteration in red cell membrane permeability, possibly in an excess of oxygen derived free radicals and physical interaction with membranes.

MeSH terms

Alcoholic Intoxication / blood
Alcoholic Intoxication / metabolism*
Animals
Brain / drug effects*
Brain / metabolism
Erythrocyte Membrane / drug effects
Ethanol / toxicity*
Lipid Peroxidation / drug effects*
Male
Oxidation-Reduction
Rats
Rats, Inbred Strains

Substances

Ethanol