Structural and functional changes in myocardial thin filaments in experimental hypothyrosis

G V Sukoyan; T M Berberashvili; K Dzh Asatiani

doi:10.1007/s10517-007-0187-7

Structural and functional changes in myocardial thin filaments in experimental hypothyrosis

Bull Exp Biol Med. 2007 May;143(5):587-9. doi: 10.1007/s10517-007-0187-7.

Authors

G V Sukoyan¹, T M Berberashvili, K Dzh Asatiani

Affiliation

¹ N V Karsanov National Center of Medical Biophysics and Introduction of New Biomedical Technologies, Tbilisi, Russia.

PMID: 18239774
DOI: 10.1007/s10517-007-0187-7

Abstract

Fluorescence resonance energy transfer study revealed decreased intermonomer mobility of Ca-actin and Mg-actin filaments of myocardial myofibrils in myocardial dystrophy caused by diffuse endocrine disorders, e. g. hypothyrosis. Cis374 axial distance in Ca-actin filament protomer increased in hypothyrosis. Intracellular pH has no effect on inter-monomer mobility of Ca-actin filament.

MeSH terms

Actins / chemistry*
Actins / metabolism
Actins / physiology*
Animals
Female
Hypothyroidism / metabolism
Hypothyroidism / physiopathology*
Male
Myocardium / metabolism*
Naphthalenesulfonates
Rats

Substances

Actins
Naphthalenesulfonates
1,5-I-AEDANS