Central nervous system relapse occurs in about 5% of cases of acute promyelocytic leukaemia

Haematologica. 2008 Feb;93(2):e28. doi: 10.3324/haematol.12207.

Abstract

In this report, we present images from a patient with acute promyelocytic leukemia who experienced several central nervous system relapses.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antineoplastic Combined Chemotherapy Protocols
  • Cell Nucleus / pathology*
  • Central Nervous System Neoplasms / cerebrospinal fluid
  • Central Nervous System Neoplasms / drug therapy
  • Central Nervous System Neoplasms / genetics
  • Central Nervous System Neoplasms / pathology*
  • Central Nervous System Neoplasms / secondary
  • Female
  • Humans
  • Idarubicin
  • Leukemia, Promyelocytic, Acute / cerebrospinal fluid
  • Leukemia, Promyelocytic, Acute / drug therapy
  • Leukemia, Promyelocytic, Acute / genetics
  • Leukemia, Promyelocytic, Acute / pathology*
  • Oncogene Proteins, Fusion / cerebrospinal fluid
  • Oncogene Proteins, Fusion / genetics
  • RNA, Neoplasm / cerebrospinal fluid
  • RNA, Neoplasm / genetics
  • Recurrence
  • Remission Induction
  • Tretinoin

Substances

  • Oncogene Proteins, Fusion
  • RNA, Neoplasm
  • promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein
  • Tretinoin
  • Idarubicin

Supplementary concepts

  • AIDA protocol