Abstract
We measured left atrial size and function from biplane MRI data in 62 adults with thalassemia major. Age-adjusted left atrial ejection fraction was depressed in 7 out of 20 subjects having T2* < 10 ms. Left atrial size, left ventricular size and cardiac output fell with cardiac iron loading, representing increased cardiac or peripheral vascular stiffness.
Publication types
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Letter
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adolescent
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Adult
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Atrial Function, Left
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Biomarkers
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Cardiac Output
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Cardiotoxins / metabolism*
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Female
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Heart Atria / metabolism
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Heart Atria / pathology
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Heart Atria / physiopathology
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Heart Diseases / metabolism*
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Heart Diseases / pathology
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Heart Diseases / physiopathology*
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Heart Ventricles / metabolism
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Heart Ventricles / pathology
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Heart Ventricles / physiopathology
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Humans
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Iron / metabolism*
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Male
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Organ Size
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beta-Thalassemia / metabolism*
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beta-Thalassemia / pathology
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beta-Thalassemia / physiopathology*
Substances
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Biomarkers
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Cardiotoxins
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Iron