Abstract
Glutamate was quantified by proton magnetic resonance spectroscopy ((1)H-MRS) in the medial frontal lobes of 15 adult siblings of individuals with schizophrenia (HR) and 14 healthy volunteers (HV), all of whom also completed a Continuous Performance Test (CPT). Subjects were free of psychopathology but the HR group showed greater variability in glutamate levels. After median stratification, the high glutamate group contained a larger proportion of HR than HV subjects and scored lower on the CPT. Elevated glutamate may relate to poor sustained attention and elevated risk of schizophrenia, suggesting a potential role for glutamate in an endophenotype for schizophrenia.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Attention / physiology*
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Cognition Disorders / diagnosis
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Cognition Disorders / genetics*
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Cognition Disorders / physiopathology
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Creatine / metabolism
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Discrimination, Psychological / physiology*
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Female
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Frontal Lobe / physiopathology*
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Genetic Predisposition to Disease / genetics
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Genetic Predisposition to Disease / psychology
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Glutamic Acid / metabolism*
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Humans
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Inhibition, Psychological
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Magnetic Resonance Spectroscopy*
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Male
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Middle Aged
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Neuropsychological Tests*
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Pattern Recognition, Visual / physiology*
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Psychomotor Performance / physiology*
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Reaction Time / physiology
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Risk
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Schizophrenia / diagnosis
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Schizophrenia / genetics*
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Schizophrenia / physiopathology
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Schizophrenic Psychology*
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Schizotypal Personality Disorder / diagnosis
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Schizotypal Personality Disorder / genetics
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Schizotypal Personality Disorder / physiopathology
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Siblings