Abstract
U-46,619 infused at 10 ng.kg-1.min-1 in anesthetized rats reduced the glomerular capillary pressure only during engagement of tubuloglomerular feedback (TGF). 100 ng.kg-1.min-1 induced renal vasoconstriction, whereas femoral vasoconstriction and a rise in BP required 1,000-10,000 ng.kg-1.min-1. These results implicate TGF in the extreme sensitivity of the kidney to TxA2/PG endoperoxide receptor activation.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
-
Animals
-
Feedback / drug effects
-
Kidney Glomerulus / drug effects*
-
Kidney Tubules / drug effects*
-
Male
-
Prostaglandin Endoperoxides, Synthetic / pharmacology*
-
Rats
-
Rats, Inbred Strains
-
Receptors, Prostaglandin / drug effects
-
Receptors, Thromboxane
-
Thromboxanes / physiology*
-
Vasoconstrictor Agents / pharmacology*
Substances
-
Prostaglandin Endoperoxides, Synthetic
-
Receptors, Prostaglandin
-
Receptors, Thromboxane
-
Thromboxanes
-
Vasoconstrictor Agents
-
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid