Central prostaglandin D(2) stimulates food intake via the neuropeptide Y system in mice

Kousaku Ohinata; Kuniko Takagi; Kyoko Biyajima; Yoko Fujiwara; Shingo Fukumoto; Naomi Eguchi; Yoshihiro Urade; Akihiro Asakawa; Mineko Fujimiya; Akio Inui; Masaaki Yoshikawa

doi:10.1016/j.febslet.2008.01.050

Central prostaglandin D(2) stimulates food intake via the neuropeptide Y system in mice

FEBS Lett. 2008 Mar 5;582(5):679-84. doi: 10.1016/j.febslet.2008.01.050. Epub 2008 Feb 5.

Authors

Kousaku Ohinata¹, Kuniko Takagi, Kyoko Biyajima, Yoko Fujiwara, Shingo Fukumoto, Naomi Eguchi, Yoshihiro Urade, Akihiro Asakawa, Mineko Fujimiya, Akio Inui, Masaaki Yoshikawa

Affiliation

¹ Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho Uji, Kyoto, Japan. [email protected]

PMID: 18258196
DOI: 10.1016/j.febslet.2008.01.050

Abstract

We found that prostaglandin (PG) D(2), the most abundant PG in the central nervous system, stimulates food intake after intracerebroventricular administration in mice. The orexigenic effect of PGD(2) was mimicked by a selective agonist for the DP(1) receptor among two receptor subtypes for PGD(2), and abolished by its antagonist. Central administration of an antagonist or antisense oligodeoxynucleotide for the DP(1) receptor remarkably decreased food intake, body weight and fat mass. Hypothalamic mRNA levels of lipocalin-type PGD synthase were up-regulated after fasting. The orexigenic activity of PGD(2) was also abolished by an antagonist for neuropeptide Y (NPY) Y(1) receptor. Taken together, PGD(2) may stimulate food intake through central DP(1) receptor coupled to the NPY system.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Appetite Depressants / pharmacology
Central Nervous System / drug effects*
Cyclooxygenase 1 / genetics
Cyclooxygenase 1 / metabolism
Cyclooxygenase 2 / genetics
Cyclooxygenase 2 / metabolism
Fasting
Feeding Behavior / drug effects*
Gene Expression Regulation / drug effects
Hypothalamus / cytology
Hypothalamus / drug effects
Hypothalamus / enzymology
Injections, Intraventricular
Intramolecular Oxidoreductases / genetics
Intramolecular Oxidoreductases / metabolism
Lipocalins / genetics
Lipocalins / metabolism
Male
Mice
Neuropeptide Y / metabolism*
Prostaglandin D2 / administration & dosage
Prostaglandin D2 / metabolism
Prostaglandin D2 / pharmacology*
Protein Transport / drug effects
RNA, Messenger / genetics
RNA, Messenger / metabolism
Receptors, Prostaglandin / genetics
Receptors, Prostaglandin / metabolism
Receptors, Prostaglandin E / genetics
Receptors, Prostaglandin E / metabolism
Receptors, Prostaglandin E, EP4 Subtype

Substances

Appetite Depressants
Lipocalins
Neuropeptide Y
Ptger4 protein, mouse
RNA, Messenger
Receptors, Prostaglandin
Receptors, Prostaglandin E
Receptors, Prostaglandin E, EP4 Subtype
prostanoid D receptor 1, mouse
Cyclooxygenase 1
Cyclooxygenase 2
Intramolecular Oxidoreductases
prostaglandin R2 D-isomerase
Prostaglandin D2

Associated data

RefSeq/NM_008962