Abstract
Voriconazole is an anti-fungal agent active against Aspergillus infection that is used for prophylaxis and curative treatment in lung transplant patients. We present nine cases of painful neuromuscular disorders, an unusual and rare side effect of high-dose voriconazole in association with tacrolimus.
MeSH terms
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Adolescent
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Adult
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Aspergillosis / drug therapy
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Cohort Studies
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Dose-Response Relationship, Drug
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Drug Administration Schedule
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Drug Interactions
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Drug Therapy, Combination
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Female
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Follow-Up Studies
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Graft Rejection / microbiology
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Graft Rejection / prevention & control*
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Humans
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Lung Transplantation / adverse effects*
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Lung Transplantation / methods
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Male
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Middle Aged
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Neuromuscular Diseases / chemically induced*
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Neuromuscular Diseases / physiopathology
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Pain / chemically induced
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Pain / physiopathology
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Postoperative Complications / microbiology
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Postoperative Complications / prevention & control
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Pyrimidines / adverse effects*
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Pyrimidines / therapeutic use
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Retrospective Studies
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Risk Assessment
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Severity of Illness Index
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Tacrolimus / therapeutic use*
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Treatment Outcome
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Triazoles / adverse effects*
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Triazoles / therapeutic use
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Voriconazole
Substances
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Pyrimidines
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Triazoles
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Voriconazole
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Tacrolimus