Leprosy reversal reaction as immune reconstitution inflammatory syndrome in patients with AIDS

Clin Infect Dis. 2008 Mar 15;46(6):e56-60. doi: 10.1086/528864.

Abstract

We report 2 instances in which reactional borderline leprosy manifested itself as an immune reconstitution phenomenon in patients with acquired immunodeficiency syndrome. We discuss the clinical, laboratory-based, histopathologic, and immunohistochemical characteristics of both patients. Furthermore, we review similar reports from the literature.

Publication types

  • Case Reports
  • Review

MeSH terms

  • AIDS-Related Opportunistic Infections / complications
  • AIDS-Related Opportunistic Infections / immunology*
  • AIDS-Related Opportunistic Infections / physiopathology
  • Adult
  • Antiretroviral Therapy, Highly Active*
  • CD4-Positive T-Lymphocytes / immunology
  • HIV Infections / complications
  • HIV Infections / immunology*
  • Humans
  • Leprosy / complications
  • Leprosy / immunology*
  • Leprosy / physiopathology*
  • Male
  • Middle Aged
  • Mycobacterium leprae / immunology