Costimulation and allergic responses: immune and bioinformatic analyses

Vipul V Jain; David L Perkins; Patricia W Finn

doi:10.1016/j.pharmthera.2007.12.002

Costimulation and allergic responses: immune and bioinformatic analyses

Pharmacol Ther. 2008 Mar;117(3):385-92. doi: 10.1016/j.pharmthera.2007.12.002. Epub 2007 Dec 23.

Authors

Vipul V Jain¹, David L Perkins, Patricia W Finn

Affiliation

¹ Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California at San Diego, San Diego, CA 92093, United States. [email protected]

PMID: 18280573
DOI: 10.1016/j.pharmthera.2007.12.002

Abstract

Asthma is a complex polygenic disease, the prevalence of which has been on the rise for last few decades. Defining the underpinnings of allergic immune responses and the factors predisposing to asthma are fundamental investigative challenges. T cell costimulatory pathways play critical roles in the pathogenesis of asthma. In this review, we analyze the current state of the art of T cell costimulation in allergic airway inflammation. Also, we discuss both immune and bioinformatic approaches as potential strategies for analyzing multiple costimulatory pathways relevant to asthma.

Publication types

Review

MeSH terms

Acute Disease
Animals
Antigens, CD / physiology
Antigens, Differentiation, T-Lymphocyte / physiology
Asthma / etiology
Asthma / immunology*
CD28 Antigens / physiology
CTLA-4 Antigen
Chronic Disease
Computational Biology
Humans
Inducible T-Cell Co-Stimulator Protein
Inflammation / immunology
Mice
Respiratory System / immunology
Signal Transduction
T-Lymphocytes / immunology*

Substances

Antigens, CD
Antigens, Differentiation, T-Lymphocyte
CD28 Antigens
CTLA-4 Antigen
CTLA4 protein, human
Ctla4 protein, mouse
ICOS protein, human
Icos protein, mouse
Inducible T-Cell Co-Stimulator Protein