Abstract
1H-tetrazole-1-alkanenitrile SR-9g exhibits a >10-fold in vivo potency enhancement over the lead nitrile 1 and has acceptable oral bioavailability in rats and dogs. An enantiospecific synthesis of 1H-tetrazole-1-alkanenitrile nitriles 9 has been developed.
MeSH terms
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Administration, Oral
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Animals
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Biological Availability
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Cytochrome P-450 Enzyme System / metabolism
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Dogs
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Growth Hormone / metabolism*
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Nitriles / chemical synthesis
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Nitriles / pharmacokinetics
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Nitriles / pharmacology*
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Pituitary Gland
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Rats
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Structure-Activity Relationship
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Tetrazoles / chemical synthesis
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Tetrazoles / pharmacokinetics
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Tetrazoles / pharmacology*
Substances
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Nitriles
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Tetrazoles
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Growth Hormone
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Cytochrome P-450 Enzyme System