Abstract
Polyomavirus BK is an important pathogen in transplant recipients with no effective therapy. This study demonstrates that alkoxyalkyl esters of (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and fatty acid derivatives of 9-[2-(phosphonomethyoxy)ethyl]adenine (P393 and P405) are potent and selective inhibitors of BK virus replication in vitro, with a 50% effective concentration in the micromolar-to-nanomolar range.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Adenine / analogs & derivatives*
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Adenine / chemistry
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Adenine / pharmacology*
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BK Virus / drug effects*
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BK Virus / physiology
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Esters / chemistry
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Fatty Acids / chemistry
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Humans
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Microbial Sensitivity Tests
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Nucleosides / chemistry
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Nucleosides / pharmacology
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Organophosphonates* / chemistry
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Organophosphonates* / pharmacology
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Virus Replication / drug effects
Substances
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Esters
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Fatty Acids
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Nucleosides
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Organophosphonates
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adefovir
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9-(S)-(3-hydroxy-2-(phosphonomethoxy)propyl)adenine
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Adenine