Abstract
Four new Daphniphyllum alkaloids, daphnioldhanines H-K ( 1- 4), along with 34 known alkaloids, were isolated from Daphniphyllum oldhami. The known alkaloid dehydrodaphnigraciline ( 5) is now reported as a natural product. Their structures were elucidated by spectroscopic methods, especially 2D NMR techniques. The effects against platelet aggregation of compounds 1, 3, and 5 were evaluated, and 3 showed stronger activity against platelet aggregation induced by PAF. This is the first report of quinolizidine alkaloids from the genus Daphniphyllum.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Alkaloids / chemistry
-
Alkaloids / isolation & purification*
-
Alkaloids / pharmacology
-
Crystallography, X-Ray
-
Drugs, Chinese Herbal / chemistry
-
Drugs, Chinese Herbal / isolation & purification*
-
Drugs, Chinese Herbal / pharmacology
-
Molecular Conformation
-
Molecular Structure
-
Nuclear Magnetic Resonance, Biomolecular
-
Plants, Medicinal / chemistry*
-
Platelet Aggregation Inhibitors / chemistry
-
Platelet Aggregation Inhibitors / isolation & purification*
-
Platelet Aggregation Inhibitors / pharmacology
-
Quinolizidines / chemistry
-
Quinolizidines / isolation & purification*
-
Quinolizidines / pharmacology
-
Saxifragaceae / chemistry*
Substances
-
Alkaloids
-
Drugs, Chinese Herbal
-
Platelet Aggregation Inhibitors
-
Quinolizidines