Halogenation strategies in natural product biosynthesis

Chem Biol. 2008 Feb;15(2):99-109. doi: 10.1016/j.chembiol.2008.01.006.

Abstract

Halogenation is a frequent modification of secondary metabolites and can play a significant role in establishing the bioactivity of a compound. Enzymatic halogenation through oxidative mechanisms is the most common route to these metabolites, though direct halogenation via halide anion incorporation is also known to proceed through both enzymatic and nonenzymatic pathways. In this article, we review the current state of knowledge regarding the mechanisms of these transformations, highlight applications of this knowledge, and propose future opportunities and challenges for the field.

Publication types

  • Review

MeSH terms

  • Biological Products / biosynthesis*
  • Biological Products / genetics
  • Biological Products / metabolism
  • Halogenation*
  • Halogens / metabolism
  • Multigene Family
  • Peroxidases / metabolism

Substances

  • Biological Products
  • Halogens
  • Peroxidases