Abstract
In this issue of the JCI, Denechaud et al. report studies investigating the role of the liver X receptors (LXRs) LXRalpha and LXRbeta in carbohydrate sensing by the liver (see the related article beginning on page 956). The results of this study, which utilized LXRalpha/beta double-KO mice, strongly contradict a recent Nature report that proposed that LXRalpha/beta sense glucose independent of metabolic flux. The reported findings further support a key role for the carbohydrate-responsive element-binding protein (ChREBP) in the regulation of lipogenic genes by glucose and dietary carbohydrates.
Publication types
-
Research Support, N.I.H., Extramural
-
Comment
MeSH terms
-
Animals
-
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
-
DNA-Binding Proteins / physiology*
-
Gene Expression Regulation*
-
Glucose / metabolism*
-
Lipogenesis
-
Liver / metabolism*
-
Liver X Receptors
-
Mice
-
Nuclear Proteins / physiology*
-
Orphan Nuclear Receptors
-
Receptors, Cytoplasmic and Nuclear / physiology*
-
Sterol Regulatory Element Binding Protein 1 / physiology
-
Transcription Factors / physiology*
Substances
-
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
-
DNA-Binding Proteins
-
Liver X Receptors
-
Mlxipl protein, mouse
-
Nr1h3 protein, mouse
-
Nuclear Proteins
-
Orphan Nuclear Receptors
-
Receptors, Cytoplasmic and Nuclear
-
Sterol Regulatory Element Binding Protein 1
-
Transcription Factors
-
Glucose