Abstract
Ellagic acid (1), 3,3'-di-O-methylellagic acid (2), 3,3',4-tri-O-methylellagic acid (3), isovitexin (4), kaempferol 3-O-beta-D-glucuronide methyl ester (5), quercetin 3-O-alpha-L-arabinopyranosyl-(1-->6)-beta-D-galactopyranoside (6), ursolic acid, pomolic acid, tormentic acid, euscaphic acid, euscaphic acid 28-O-beta-D-glucopyranoside, and maslinic acid were isolated from the AcOEt- and BuOH-soluble MeOH extract of Duchesnea chrysantha (whole plant). The isolates were subjected to in vitro bioassays to evaluate their inhibitory activity on rat-lens aldose reductase (RLAR) and formation of advanced glycation end products (AGEs). The ellagic acids and flavonoids, compounds 1-6, exhibited moderate inhibitory effects on RLAR. However, compounds 1 and 4-6 showed excellent inhibitory activities towards the formation of AGEs. This is the first report that 4 and 6 exhibit inhibitory activity towards AR and AGEs formation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aldehyde Reductase / antagonists & inhibitors*
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Animals
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Apigenin / chemistry
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Apigenin / isolation & purification
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Apigenin / pharmacology
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Ellagic Acid / analogs & derivatives
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Ellagic Acid / chemistry
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Ellagic Acid / isolation & purification
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Ellagic Acid / pharmacology
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Glycation End Products, Advanced / antagonists & inhibitors*
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Glycosides / chemistry
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Glycosides / isolation & purification
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Glycosides / pharmacology*
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Lens, Crystalline / enzymology
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Molecular Structure
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Oleanolic Acid / analogs & derivatives
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Oleanolic Acid / chemistry
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Oleanolic Acid / isolation & purification
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Oleanolic Acid / pharmacology
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Quercetin / chemistry
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Quercetin / isolation & purification
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Quercetin / pharmacology*
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Rats
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Rats, Sprague-Dawley
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Rosaceae / chemistry*
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Stereoisomerism
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Structure-Activity Relationship
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Triterpenes / chemistry
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Triterpenes / isolation & purification
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Triterpenes / pharmacology
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Ursolic Acid
Substances
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Glycation End Products, Advanced
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Glycosides
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Triterpenes
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Ellagic Acid
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3,3'-di-O-methylellagic acid
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euscaphic acid
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pomolic acid
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Oleanolic Acid
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Apigenin
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Quercetin
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maslinic acid
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Aldehyde Reductase
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isovitexin