Nucleotide sequence to a teicoplanin resistance gene from Actinoplanes teichomyceticus

M Sosio; R Lorenzetti; F Robbiati; M Denaro

doi:10.1016/0167-4781(91)90185-o

Nucleotide sequence to a teicoplanin resistance gene from Actinoplanes teichomyceticus

Biochim Biophys Acta. 1991 Jul 23;1089(3):401-3. doi: 10.1016/0167-4781(91)90185-o.

Authors

M Sosio¹, R Lorenzetti, F Robbiati, M Denaro

Affiliation

¹ Lepetit Research Center, M.M.D.R.I., Gerenzano, Italy.

PMID: 1830492
DOI: 10.1016/0167-4781(91)90185-o

Abstract

A DNA fragment, isolated from A. teichomyceticus and able to confer teicoplanin resistance in a sensitive host, has been sequenced. It reveals the presence of two open reading frames (ORFs) positioned on opposite strands, named ORF1 and ORF2. ORF2 seems to be responsible for the acquisition of the resistance character.

MeSH terms

Actinomycetales / genetics*
Amino Acid Sequence
Anti-Bacterial Agents*
Base Sequence
Cloning, Molecular
DNA, Bacterial
Drug Resistance, Microbial / genetics
Genes, Bacterial*
Glycopeptides / pharmacology
Molecular Sequence Data
Restriction Mapping
Streptomyces / genetics
Teicoplanin

Substances

Anti-Bacterial Agents
DNA, Bacterial
Glycopeptides
Teicoplanin