Abstract
The compound L-valine-3-{8-[(E)-2-[3-methoxyphenyl)ethenyl]-7-methyl-1-propargylxanthine-3-yl}propyl ester hydrochloride (MSX-4) was synthesized as an amino acid ester prodrug of the adenosine A2A receptor antagonist MSX-2. It was found to be stable in artificial gastric acid, but readily cleaved by pig liver esterase.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenosine A2 Receptor Antagonists*
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Animals
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Carboxylesterase / metabolism
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Dimerization
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Drug Stability
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Hydrogen-Ion Concentration / drug effects
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Hydrolysis / drug effects
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Prodrugs / chemical synthesis*
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Prodrugs / pharmacology*
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Solubility / drug effects
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Swine
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Water / metabolism*
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Xanthines / chemical synthesis*
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Xanthines / chemistry
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Xanthines / pharmacology*
Substances
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3-(3-hydroxypropyl)-8-(3-methoxystyryl)-7-methyl-1-propargylxanthine
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Adenosine A2 Receptor Antagonists
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Prodrugs
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Xanthines
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Water
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Carboxylesterase