A near-infrared-fluorescence-quenched gold-nanoparticle imaging probe for in vivo drug screening and protease activity determination

Angew Chem Int Ed Engl. 2008;47(15):2804-7. doi: 10.1002/anie.200705240.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / analysis*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Cell Line, Tumor
  • Drug Screening Assays, Antitumor / instrumentation*
  • Drug Screening Assays, Antitumor / methods*
  • Gold / chemistry*
  • Humans
  • Metal Nanoparticles / chemistry*
  • Metal Nanoparticles / ultrastructure
  • Mice
  • Mice, Nude
  • Microscopy, Electron, Transmission
  • Peptide Hydrolases / analysis
  • Peptide Hydrolases / metabolism*
  • Protease Inhibitors / analysis*
  • Protease Inhibitors / chemistry
  • Protease Inhibitors / pharmacology
  • Spectrometry, Fluorescence
  • Spectrophotometry, Infrared

Substances

  • Antineoplastic Agents
  • Protease Inhibitors
  • Gold
  • Peptide Hydrolases