Abstract
Hormesis refers to the beneficial effects of a treatment that at a higher intensity is harmful. In one form of hormesis, sublethal exposure to stressors induces a response that results in stress resistance. The principle of stress-response hormesis is increasingly finding application in studies of aging, where hormetic increases in life span have been seen in several animal models.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adaptation, Physiological
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Aging / metabolism*
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Animals
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Biotransformation
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Caloric Restriction
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Dose-Response Relationship, Drug
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Environmental Pollutants / pharmacology*
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Environmental Pollutants / toxicity
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Humans
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Insulin / metabolism
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Insulin-Like Growth Factor I / metabolism
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Longevity / drug effects*
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Signal Transduction / drug effects*
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Stress, Physiological / chemically induced
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Stress, Physiological / metabolism*
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Stress, Physiological / physiopathology
Substances
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Environmental Pollutants
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Insulin
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Insulin-Like Growth Factor I