Abstract
Effect of synthetic analogues of atrial natriuretic factor (ANF) on proliferative response and natural cytotoxic lymphocytes of human subjects was investigated in vitro. ANF-III and ANF-IV increased blast transformation lymphocytes induced by a Con-A suboptimal dose. The increase of cells activity was comparable with the effect of interleukin-2, added at a dose of 50-100 unit/ml.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Atrial Natriuretic Factor*
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Blood Donors
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Cardiomyopathy, Dilated / immunology
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Cells, Cultured
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Concanavalin A / pharmacology
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Cytotoxicity Tests, Immunologic
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Cytotoxicity, Immunologic*
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Humans
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Interleukin-2 / pharmacology
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Lymphocyte Activation / drug effects*
Substances
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Interleukin-2
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NPPA protein, human
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Concanavalin A
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Atrial Natriuretic Factor