Abstract
The therapeutic efficacy of wiferon (recombinant alpha2beta-interferon) versus arbidol was studied in a double-blind controlled study in patients with laboratorily verified influenza. Within the first 24-36 hours after the onset of the disease, wiferon and arbidol reduced the duration of fever, intoxication, and the catarrhal symptoms of the disease as a whole. The agents were shown to have an immunomodulating effect.
Publication types
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Clinical Trial
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Randomized Controlled Trial
MeSH terms
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Administration, Rectal
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Adolescent
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Adult
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Antiviral Agents / administration & dosage
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Antiviral Agents / therapeutic use*
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Cough / drug therapy
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Double-Blind Method
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Fever / drug therapy
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Humans
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Indoles / administration & dosage
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Indoles / therapeutic use*
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Influenza, Human / blood
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Influenza, Human / drug therapy*
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Influenza, Human / immunology
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Interferon alpha-2
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Interferon-alpha / administration & dosage
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Interferon-alpha / therapeutic use*
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Interferons / biosynthesis
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Interferons / blood
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Leukocytes / immunology
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Leukocytes / metabolism
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Lymphocyte Count
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Middle Aged
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Recombinant Proteins
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Rhinitis / drug therapy
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Suppositories / administration & dosage
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Suppositories / therapeutic use
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Treatment Outcome
Substances
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Antiviral Agents
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Indoles
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Interferon alpha-2
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Interferon-alpha
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Recombinant Proteins
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Suppositories
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Interferons
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umifenovir