Abstract
A leading complication of leukemia therapy and stem cell transplantation is opportunistic viral infections. Infections caused by cytomegalovirus, herpes simplex, varicella-zoster, Epstein-Barr, and the community respiratory viruses are associated with significant morbidity and mortality in this highly immunosuppressed population. Fortunately, a growing armamentarium is allowing more effective prophylaxis of these pathogens. This article reviews the epidemiology and prophylactic strategies available for these common opportunistic viral pathogens.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Antiviral Agents / administration & dosage
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Benzimidazoles / administration & dosage
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Cytomegalovirus Infections / drug therapy
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Cytomegalovirus Infections / prevention & control
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Foscarnet / administration & dosage
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Ganciclovir / administration & dosage
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Herpes Zoster / drug therapy
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Herpes Zoster / prevention & control
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Humans
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Immune Sera / administration & dosage
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Immunization, Passive
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Immunocompromised Host*
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Leukemia / epidemiology
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Leukemia / surgery*
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Opportunistic Infections / drug therapy
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Opportunistic Infections / prevention & control*
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Ribonucleosides / administration & dosage
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Stem Cell Transplantation*
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Virus Diseases / drug therapy
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Virus Diseases / epidemiology
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Virus Diseases / prevention & control*
Substances
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Antiviral Agents
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Benzimidazoles
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Immune Sera
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Ribonucleosides
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varicella-zoster immune globulin
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Foscarnet
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Ganciclovir
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maribavir