The link between IL-23 and Th17 cell-mediated immune pathologies

Mandy J McGeachy; Daniel J Cua

doi:10.1016/j.smim.2007.10.012

The link between IL-23 and Th17 cell-mediated immune pathologies

Semin Immunol. 2007 Dec;19(6):372-6. doi: 10.1016/j.smim.2007.10.012. Epub 2007 Dec 3.

Authors

Mandy J McGeachy¹, Daniel J Cua

Affiliation

¹ Schering-Plough Biopharma (Formerly DNAX Research), 901 California Avenue, Palo Alto, CA 94304, United States. [email protected]

PMID: 18319054
DOI: 10.1016/j.smim.2007.10.012

Abstract

IL-23--produced by dendritic cells--and Th17 cells have both been identified as major factors involved in autoimmune inflammation, yet their relationship with each other remains controversial. This review aims to describe the initial discovery of Th17 cells, their subsequent characterization as a unique T helper subset in mouse and man, as well as the mechanisms involved in regulating these cells. Finally, the roles of IL-23 in inflammatory diseases in relation to Th17 function will be discussed.

Publication types

Review

MeSH terms

Animals
Cytokines / immunology
Cytokines / metabolism
Dendritic Cells / immunology*
Dendritic Cells / metabolism
Humans
Inflammation / immunology*
Inflammation / metabolism
Interleukin-17 / immunology*
Interleukin-17 / metabolism
Interleukin-23 / immunology*
Interleukin-23 / metabolism
T-Lymphocyte Subsets / immunology
T-Lymphocyte Subsets / metabolism
T-Lymphocytes, Helper-Inducer / immunology*
T-Lymphocytes, Helper-Inducer / metabolism

Substances

Cytokines
Interleukin-17
Interleukin-23