Correlation of intra-tumour heterogeneity on 18F-FDG PET with pathologic features in non-small cell lung cancer: a feasibility study

Angela van Baardwijk; Geert Bosmans; Robert Jan van Suylen; Marinus van Kroonenburgh; Monique Hochstenbag; Gijs Geskes; Philippe Lambin; Dirk De Ruysscher

doi:10.1016/j.radonc.2008.02.002

Correlation of intra-tumour heterogeneity on 18F-FDG PET with pathologic features in non-small cell lung cancer: a feasibility study

Radiother Oncol. 2008 Apr;87(1):55-8. doi: 10.1016/j.radonc.2008.02.002. Epub 2008 Mar 6.

Authors

Angela van Baardwijk¹, Geert Bosmans, Robert Jan van Suylen, Marinus van Kroonenburgh, Monique Hochstenbag, Gijs Geskes, Philippe Lambin, Dirk De Ruysscher

Affiliation

¹ Department of Radiation Oncology (MAASTRO), GROW , University Hospital Maastricht, Maastricht, The Netherlands. [email protected]

PMID: 18328584
DOI: 10.1016/j.radonc.2008.02.002

Abstract

We evaluated the feasibility to correlate intra-tumour heterogeneity as visualized on 18F-FDG PET with histology for NSCLC. For this purpose we used an ex-vivo model. The procedure was feasible in all operated patients. We have shown that this method is suitable for correlating intra-tumour heterogeneity in tracer uptake with histology.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Biopsy
Carcinoma, Non-Small-Cell Lung / diagnostic imaging*
Carcinoma, Non-Small-Cell Lung / pathology
Carcinoma, Non-Small-Cell Lung / radiotherapy*
Chi-Square Distribution
Feasibility Studies
Female
Fluorodeoxyglucose F18
Humans
Lung Neoplasms / diagnostic imaging*
Lung Neoplasms / pathology
Lung Neoplasms / radiotherapy*
Male
Middle Aged
Positron-Emission Tomography*
Radiopharmaceuticals

Substances

Radiopharmaceuticals
Fluorodeoxyglucose F18