Atomic structure of a short alpha-helix stabilized by a main chain hydrogen-bond surrogate

J Am Chem Soc. 2008 Apr 2;130(13):4334-7. doi: 10.1021/ja077704u. Epub 2008 Mar 11.

Abstract

Herein we report the 1.15 A X-ray crystal structure of a short alpha-helix in which the N-terminal i and i + 4 main chain hydrogen bond is replaced with a carbon-carbon bond. The structure shows that the hydrogen-bond surrogate (HBS) derived alpha-helix truly resembles the structure of canonical alpha-helices and provides unequivocal support for our helix nucleation strategy.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Crystallography, X-Ray
  • Hydrogen Bonding
  • Magnetic Resonance Spectroscopy / methods
  • Models, Molecular
  • Peptides / chemistry*
  • Protein Conformation
  • Protein Structure, Secondary

Substances

  • Peptides