Abstract
We investigated the antistaphylococcal activities of daptomycin, gentamicin, and rifampin against two Staphylococcus aureus strains and their stable small-colony variants, singly and in combination, in human monocyte-derived macrophages and in broth. Intracellularly, the three-drug combination and two-drug combinations with rifampin were most effective. Extracellularly, daptomycin, daptomycin plus gentamicin, gentamicin plus rifampin, and the three-drug combination had similar activities.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Cells, Cultured
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Daptomycin / pharmacology*
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Gentamicins / pharmacology
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Humans
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Macrophages / cytology
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Macrophages / drug effects*
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Macrophages / virology
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Microbial Sensitivity Tests
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Monocytes / cytology
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Monocytes / drug effects
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Monocytes / virology
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Rifampin / pharmacology
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Staphylococcus aureus / drug effects*
Substances
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Anti-Bacterial Agents
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Gentamicins
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Daptomycin
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Rifampin