Abstract
In this study, we synthesized some new substituted steroidal derivatives using 3beta-hydroxyandrosten-17-one (dehydroepiandrosterone) as starting material. The synthesized steroidal derivatives 1-11 were evaluated for their androgenic-anabolic activities compared to testosterone as positive control. Details of the synthesis, spectroscopic data and toxicity (LD50) of synthesized compounds are reported.
MeSH terms
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Anabolic Agents / chemical synthesis*
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Anabolic Agents / chemistry
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Anabolic Agents / pharmacology
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Androgens / chemical synthesis*
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Androgens / chemistry
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Androgens / pharmacology
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Androstanols / chemical synthesis*
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Androstanols / chemistry
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Androstanols / pharmacology
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Androstanols / toxicity
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Androstenes / chemical synthesis*
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Androstenes / chemistry
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Androstenes / pharmacology
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Androstenes / toxicity
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Animals
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Dehydroepiandrosterone / analogs & derivatives*
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Dehydroepiandrosterone / chemistry
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Drug Design*
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Drug Evaluation, Preclinical
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Genitalia, Male / drug effects
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Lethal Dose 50
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Male
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Molecular Structure
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Muscles / drug effects
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Organ Size
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Rats
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Rats, Sprague-Dawley
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Structure-Activity Relationship
Substances
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Anabolic Agents
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Androgens
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Androstanols
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Androstenes
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Dehydroepiandrosterone