Abstract
In the presence of antigen presenting cells, a murine T helper (Th) cell specific for murine hemoglobin (Hb) responded to its immunogenic peptide by both cytokine (interleukin-4) secretion and proliferation. An altered Hb peptide with a single amino acid substitution induced only cytokine secretion and did not induce proliferation. Interleukin-1 costimulated and restored the Th proliferative response to normal levels. The altered peptide also supported cognate T cell-B cell interactions indicative of T cell helper function. Thus, this result suggests that the T cell receptor has the capacity of differential signaling.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Cell Division
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Clone Cells
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Hemoglobins / chemistry
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Hemoglobins / immunology*
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Interleukin-4 / biosynthesis*
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Lymphocyte Activation / immunology*
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Mice
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Molecular Sequence Data
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Peptide Fragments / chemistry
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Peptide Fragments / immunology*
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Receptors, Antigen, T-Cell / immunology
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Receptors, Antigen, T-Cell / metabolism*
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Signal Transduction
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T-Lymphocytes, Helper-Inducer / cytology
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T-Lymphocytes, Helper-Inducer / immunology*
Substances
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Hemoglobins
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Peptide Fragments
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Receptors, Antigen, T-Cell
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Interleukin-4