Sclerodermiform linear lupus erythematosus: A distinct entity or coexistence of two autoimmune diseases?

J Am Acad Dermatol. 2008 Apr;58(4):665-7. doi: 10.1016/j.jaad.2007.06.044.

Abstract

The coexistence of features of chronic cutaneous lupus erythematosus and scleroderma in the same skin lesions is very infrequent and has only been reported in 3 patients. This exceedingly rare condition has been named "sclerodermiform linear lupus erythematosus." We describe a new case of this dermatosis. Although the cause remains obscure, possible explanations include mosaicism following Blaschko's lines or the transfer of microchimerisms that mount a chronic graft-versus-host-like reaction. We suggest that these features may be a distinct clinicopathologic disorder characterized by an initial lichenoid reaction followed by the production of excessive, abnormal connective tissue.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Autoimmune Diseases*
  • Humans
  • Lupus Erythematosus, Discoid / complications*
  • Lupus Erythematosus, Discoid / pathology
  • Scleroderma, Localized / complications*
  • Scleroderma, Localized / pathology