Abstract
Humoral immune mechanisms may have a role in the neurological complications of celiac disease (CD). We assessed 71 CD patients for neurologic manifestations and presence of serum antibodies to neural antigens. Sixteen patients (22.5%) were found to have neurological deficits including headache, depression, entrapment syndromes, peripheral neuropathy, and epilepsy. Antibody reactivity to neural antigens was detected in 30/71 (42.2%) patients. There was no clear correlation between anti-neural reactivity and neurologic dysfunction. Follow-up of 62 patients did not reveal change in electrophysiology or antibodies, regardless of diet. However, in 2 patients with neuropathy, symptoms improved or worsened depending on the diet.
MeSH terms
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Action Potentials / physiology
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Action Potentials / radiation effects
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Adult
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Antibodies / blood
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Blood Cell Count
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Celiac Disease / blood
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Celiac Disease / complications*
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Celiac Disease / immunology*
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Female
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Follow-Up Studies
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GTP-Binding Proteins
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Gangliosides / immunology
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Gliadin / immunology
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HLA Antigens
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Humans
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Male
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Middle Aged
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Nervous System Diseases / blood
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Nervous System Diseases / classification
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Nervous System Diseases / etiology*
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Nervous System Diseases / immunology*
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Neural Conduction / physiology
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Prospective Studies
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Protein Glutamine gamma Glutamyltransferase 2
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Transglutaminases / immunology
Substances
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Antibodies
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Gangliosides
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HLA Antigens
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Gliadin
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Protein Glutamine gamma Glutamyltransferase 2
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Transglutaminases
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GTP-Binding Proteins