Abstract
New analogues of the potent antihelmintic meclonazepam were prepared and evaluated against Schistosoma mansoni. The biological data suggests substitution at positions 2 and 4 of meclonazepam could provide promising analogues for prophylactic and therapeutic activity against S. mansoni.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anthelmintics / chemical synthesis
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Anthelmintics / pharmacology*
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Benzodiazepinones / chemical synthesis
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Benzodiazepinones / pharmacology*
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Models, Chemical
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Schistosoma mansoni / drug effects*
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Anthelmintics
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Benzodiazepinones
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meclonazepam