The GTPase CpgA is implicated in the deposition of the peptidoglycan sacculus in Bacillus subtilis

J Bacteriol. 2008 May;190(10):3786-90. doi: 10.1128/JB.01994-07. Epub 2008 Mar 14.

Abstract

Depletion of the Bacillus subtilis GTPase CpgA produces abnormal cell shapes, nonuniform deposition of cell wall, and five- to sixfold accumulation of peptidoglycan precursors. Nevertheless, the inherent structure of the cell wall appeared mostly unchanged. The results are consistent with CpgA being involved in coordinating normal peptidoglycan deposition.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacillus subtilis / enzymology*
  • Bacillus subtilis / genetics
  • Bacillus subtilis / metabolism*
  • Cell Wall / chemistry
  • Cell Wall / metabolism*
  • GTP Phosphohydrolases / metabolism*
  • Genes, Bacterial
  • Peptidoglycan / analysis
  • Peptidoglycan / metabolism*

Substances

  • Peptidoglycan
  • GTP Phosphohydrolases