Abstract
An outbreak of cephalosporin-resistant Klebsiella pneumoniae occurred in a neonatal intensive care unit in São Paulo, Brazil. Of the 10 pulsotypes identified during the outbreak and follow-up periods, nine produced CTX-M-2 or its new variant CTX-M-59 and one produced SHV-5. bla(CTX-M-2/59) genes were located on closely related plasmids that were transferable.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism*
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Brazil / epidemiology
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Cephalosporins / pharmacology
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Disease Outbreaks
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Drug Resistance, Bacterial
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Electrophoresis, Gel, Pulsed-Field
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Humans
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Infant, Newborn
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Intensive Care Units, Neonatal*
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Klebsiella Infections / epidemiology
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Klebsiella Infections / microbiology
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Klebsiella pneumoniae / enzymology*
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Klebsiella pneumoniae / genetics
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Klebsiella pneumoniae / isolation & purification
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Mutation
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Polymerase Chain Reaction
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beta-Lactamases / genetics
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beta-Lactamases / metabolism*
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Cephalosporins
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beta-lactamase CTX-2
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beta-Lactamases
Associated data
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GENBANK/DQ322460
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GENBANK/DQ408762