[A case of advanced gastric cancer responding to neoadjuvant S-1/CDDP therapy]

Gan To Kagaku Ryoho. 2008 Mar;35(3):499-501.
[Article in Japanese]

Abstract

A 77-year-old male had complaints of epigastralgia. Gastrointestinal endoscopic examination revealed type 2 advanced gastric cancer. Computed tomography revealed metastatic Bulkey group 2 lymph nodes. The diagnosis was sStage IIIB gastric cancer (sT3 sN2sH0 sP0 CY0) at staging laparoscopy. S-1 (100 mg/body/day) was orally administered for 3 weeks followed by a drug-free 2 weeks, and CDDP (74 mg/body/day) was given intravenously on day 8. After 3 courses of chemotherapy, the primary lesion and the regional lymph nodes were significantly reduced in size. He was judged as clinical PR, followed by total gastrectomy, splenectomy and lymph node dissection. The pathological findings showed that there were very few cancer cells in the primary lesion, and lymph nodes had become scarred and fibrous. The final diagnosis was T2N0 H0 P0, fStageIB and curability A.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Cisplatin / therapeutic use*
  • Drug Combinations
  • Humans
  • Male
  • Neoadjuvant Therapy*
  • Neoplasm Staging
  • Oxonic Acid / therapeutic use*
  • Stomach Neoplasms / diagnostic imaging
  • Stomach Neoplasms / drug therapy*
  • Stomach Neoplasms / pathology*
  • Stomach Neoplasms / surgery
  • Tegafur / therapeutic use*
  • Tomography, X-Ray Computed

Substances

  • Drug Combinations
  • S 1 (combination)
  • Tegafur
  • Oxonic Acid
  • Cisplatin