Proximicins A, B, and C-antitumor furan analogues of netropsin from the marine actinomycete Verrucosispora induce upregulation of p53 and the cyclin kinase inhibitor p21

Angew Chem Int Ed Engl. 2008;47(17):3258-61. doi: 10.1002/anie.200705295.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actinobacteria / chemistry
  • Antineoplastic Agents / pharmacology*
  • Cyclin-Dependent Kinase Inhibitor p21 / genetics*
  • Furans
  • Molecular Structure
  • Netropsin / analogs & derivatives*
  • Netropsin / chemistry
  • Netropsin / isolation & purification
  • Netropsin / pharmacology*
  • Tumor Suppressor Protein p53 / genetics*
  • Up-Regulation / drug effects*

Substances

  • Antineoplastic Agents
  • Cyclin-Dependent Kinase Inhibitor p21
  • Furans
  • Tumor Suppressor Protein p53
  • proximicin A
  • proximicin B
  • proximicin C
  • Netropsin
  • furan