Balamuthia mandrillaris resistance to hostile conditions

Ruqaiyyah Siddiqui; Antonio Ortega-Rivas; Naveed Ahmed Khan

doi:10.1099/jmm.0.47694-0

Balamuthia mandrillaris resistance to hostile conditions

J Med Microbiol. 2008 Apr;57(Pt 4):428-431. doi: 10.1099/jmm.0.47694-0.

Authors

Ruqaiyyah Siddiqui¹, Antonio Ortega-Rivas², Naveed Ahmed Khan¹

Affiliations

¹ School of Biological and Chemical Sciences, Birkbeck College, University of London, London WC1E 7HX, UK.
² Department of Parasitology, La Laguna University, La Laguna, Canary Islands, Spain.

PMID: 18349360
DOI: 10.1099/jmm.0.47694-0

Abstract

The resistance of Balamuthia mandrillaris to physical, chemical and radiological conditions was tested. Following treatments, viability was determined by culturing amoebae on human brain microvascular endothelial cells for up to 12 days. B. mandrillaris cysts were resistant to repeated freeze-thawing (five times), temperatures of up to 70 degrees C, 0.5 % SDS, 25 p.p.m. chlorine, 10 microg pentamidine isethionate ml(-1) and 200 mJ UV irradiation cm(-2).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Brain / blood supply
Cells, Cultured
Chlorine / pharmacology
Endothelial Cells / parasitology
Endothelium, Vascular / cytology
Endothelium, Vascular / parasitology
Freezing
Heat-Shock Response*
Hot Temperature
Humans
Lobosea* / drug effects
Lobosea* / growth & development
Lobosea* / radiation effects
Pentamidine / pharmacology
Sodium Dodecyl Sulfate / pharmacology
Trophozoites* / drug effects
Trophozoites* / growth & development
Trophozoites* / radiation effects
Ultraviolet Rays

Substances

Sodium Dodecyl Sulfate
Chlorine
Pentamidine