Adverse facial edema associated with off-label use of recombinant human bone morphogenetic protein-2 in cranial reconstruction for craniosynostosis. Case report

J Neurosurg Pediatr. 2008 Mar;1(3):255-7. doi: 10.3171/PED/2008/1/3/255.

Abstract

The authors present a case of scalp and facial edema following craniofacial reconstruction for metopic craniosynostosis in which recombinant human bone morphogenetic protein-2 (rhBMP-2) was used to treat cranial defects related to the frontoorbital reconstruction. The extent of swelling, the onset, and duration were unusual for such cases and suggested a possible role of rhBMP-2 in inducing a local inflammatory response. The edema rapidly resolved after the patient underwent surgery to remove the rhBMP-2 implants.

Publication types

  • Case Reports

MeSH terms

  • Bone Morphogenetic Protein 2
  • Bone Morphogenetic Proteins / adverse effects*
  • Bone Plates
  • Child, Preschool
  • Cranial Sutures / abnormalities
  • Cranial Sutures / surgery
  • Craniosynostoses / surgery*
  • Craniotomy
  • Drug Implants
  • Edema / chemically induced*
  • Facial Dermatoses / chemically induced*
  • Frontal Bone / abnormalities
  • Frontal Bone / surgery
  • Humans
  • Male
  • Orbit / surgery
  • Plastic Surgery Procedures / adverse effects*
  • Recombinant Proteins
  • Scalp Dermatoses / chemically induced
  • Transforming Growth Factor beta / adverse effects*

Substances

  • BMP2 protein, human
  • Bone Morphogenetic Protein 2
  • Bone Morphogenetic Proteins
  • Drug Implants
  • Recombinant Proteins
  • Transforming Growth Factor beta