Association study of the HLA-A2 allele in Italian Alzheimer disease patients

Franca Rosa Guerini; Elena Calabrese; Cristina Agliardi; Milena Zanzottera; Massimo Franceschi; Luigi Maria Edoardo Grimaldi; Raffaello Nemni; Pasquale Ferrante

doi:10.1016/j.neurobiolaging.2008.02.001

Association study of the HLA-A2 allele in Italian Alzheimer disease patients

Neurobiol Aging. 2009 Dec;30(12):2082-3. doi: 10.1016/j.neurobiolaging.2008.02.001. Epub 2008 Mar 21.

Authors

Franca Rosa Guerini¹, Elena Calabrese, Cristina Agliardi, Milena Zanzottera, Massimo Franceschi, Luigi Maria Edoardo Grimaldi, Raffaello Nemni, Pasquale Ferrante

Affiliation

¹ Laboratory of Molecular Medicine and Biotechnology, Don C. Gnocchi Foundation IRCCS, Milan, Italy. [email protected]

PMID: 18359130
DOI: 10.1016/j.neurobiolaging.2008.02.001

Abstract

Association of the A2 allele of the human leukocyte antigen (HLA) with Alzheimer disease (AD) is still controversial. The authors evaluated HLA-A2 association with AD in 173 Italian AD patients, considering also the possible interaction with APOE pattern, age of onset and gender. No evidence of any association was found.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Age of Onset
Aged
Alleles
Alzheimer Disease / epidemiology
Alzheimer Disease / genetics*
Apolipoprotein E4 / genetics
Female
Genetic Association Studies
Genotype
HLA-A2 Antigen / genetics*
Humans
Italy / epidemiology
Male
Middle Aged
Phenotype
Sequence Analysis, DNA
Sex Factors

Substances

Apolipoprotein E4
HLA-A2 Antigen