Phylogeny of Lagos bat virus: challenges for lyssavirus taxonomy

Virus Res. 2008 Jul;135(1):10-21. doi: 10.1016/j.virusres.2008.02.001. Epub 2008 Mar 24.

Abstract

Lagos bat virus (LBV) belongs to genotype 2 of the Lyssavirus genus. The complete nucleoprotein (N), phosphoprotein (P), matrixprotein (M) and glycoprotein (G) genes of 13 LBV isolates were sequenced and phylogenetically compared with other lyssavirus representatives. The results identified three different lineages of LBV. One of these lineages demonstrated sufficient sequence diversity to be considered a new lyssavirus genotype (Dakar bat lyssavirus). The suggested quantitative separation of lyssavirus genotypes using the N, P, M and G genes was also investigated using P-distances matrixes. Results indicated that the current criteria should be revised since overlaps between intergenotypic and intragenotypic variation occur.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Genetic Variation
  • Genotype
  • Glycoproteins / genetics
  • Humans
  • Lyssavirus / classification*
  • Lyssavirus / genetics*
  • Lyssavirus / isolation & purification
  • Molecular Sequence Data
  • Nucleoproteins / genetics
  • Nucleoproteins / metabolism
  • Phosphoproteins / genetics
  • Phylogeny*
  • Rhabdoviridae Infections / veterinary*
  • Rhabdoviridae Infections / virology*
  • Sequence Homology
  • Viral Proteins / genetics

Substances

  • Glycoproteins
  • Nucleoproteins
  • Phosphoproteins
  • Viral Proteins