[Detection of inflammation in an atherosclerose plaque: the role of the positron emission tomography and C reactive protein]

Arch Cardiol Mex. 2007 Oct-Dec;77(4):288-94.
[Article in Spanish]

Abstract

Objectives: To demonstrate that inflammatory atheromatose carotid plaques can be visualized with positron emission tomography with 18F-fluorodeoxyglucose (18FDG PET) in symptomatic patients, in order to correlate them with systemic inflammatory markers, such as CRP.

Method: Fifteen patients with cerebral ischemia due to atherosclerotic carotid disease were studied. 18FDG uptake with PET was considered and blood samples were taken for determining high sensibility C reactive protein (HsCRP).

Results: The mean age of the patients was 66 years; 11 of them were males (73%) and 4 were females (27%). 18FDG PET was positive in 12 patients (80%), while 100% of the studied population had low risk HsCRP with normal white cell count.

Conclusions: 18FDG PET proves active inflammation in carotid atheromatose plaques. There was no significant correlation between the presence of ahteromatose carotid plaques, HsCRP serum levels, and 18FDG PET study.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Aged, 80 and over
  • C-Reactive Protein / analysis*
  • Carotid Artery Diseases / blood*
  • Carotid Artery Diseases / diagnosis*
  • Carotid Artery Diseases / diagnostic imaging
  • Female
  • Humans
  • Inflammation / blood
  • Male
  • Middle Aged
  • Positron-Emission Tomography*
  • Prospective Studies

Substances

  • C-Reactive Protein