Abstract
The expression of the mos proto-oncogene was investigated in frozen sections from 15 ovarian adenocarcinomas, 1 seminoma, 1 immature teratoma and 2 benign stromal tumors by in situ RNA/RNA hybridization with a [35S] labeled mos probe. The presence of mos transcripts was detected in one germ cell tumor and three ovarian carcinomas. The putative role of the mos proto-oncogene activation is discussed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenocarcinoma / genetics*
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Adenocarcinoma / pathology
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Aged
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Dysgerminoma / genetics
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Dysgerminoma / pathology
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Female
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Gene Expression
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Genes, mos*
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Humans
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Neoplasm Invasiveness
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Ovarian Neoplasms / genetics*
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Ovarian Neoplasms / pathology
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Ovary / cytology
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Ovary / physiology
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Protein-Tyrosine Kinases / analysis
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Proto-Oncogene Mas
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Proto-Oncogene Proteins / analysis
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Proto-Oncogene Proteins c-mos
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RNA, Neoplasm / analysis
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RNA, Neoplasm / genetics
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Teratoma / genetics
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Teratoma / pathology
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Transcription, Genetic
Substances
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MAS1 protein, human
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Proto-Oncogene Mas
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Proto-Oncogene Proteins
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RNA, Neoplasm
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Protein-Tyrosine Kinases
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Proto-Oncogene Proteins c-mos